Groundbreaking study: low carb is an effective treatment for fatty liver

March 11 2018 by , medical review by in Liver disease, New study

The following is a guest post by Ann Fernholm, author, science journalist and PhD in molecular biotechnology. She is the founder of the not-for-profit Dietary Science Foundation.

Approximately 25 percent of adults in the Western world have fatty liver and are thus at an increased risk of developing cirrhosis, liver cancer, type 2 diabetes and cardiovascular disease. Fatty liver is considered a chronic disease, but researchers at the University of Gothenburg have now proven that it is possible to get rid of the liver fat in just two weeks. The medication is called: a strict low carb or keto diet.

Fatty liver – what is that? You might wonder, and perhaps think that this is referring to that fat-rich paté which the French love. But fatty liver is one of the most common HIDDEN diseases in the world. In earlier decades, fatty liver was mostly associated with alcoholism, but in the footprints of the obesity epidemic, the frequency of the disease has sky rocketed. Approximately one out of every ten adolescents in both Europe and the US have the disease today.

A little fat in the liver is not harmful (given that you’re not a goose and thus are at risk of becoming paté), but in the long run the liver risks becoming inflamed and the liver cells can die. A fatty liver also increases the risk of developing cirrhosis, type 2 diabetes and cardiovascular disease. To avoid this, people need to get the fat out of the liver.

The advice given to people with fatty liver has been to exercise, count calories and lose weight, but – as we all know – most people fail and the fat remains in the same place. That’s why it is an important breakthrough that researchers at the University of Gothenburg have showed that the fat can go away without substantial weight loss. The participants in the study simply continued to eat the same amount of calories, but swapped carbs for protein. Within just two weeks, the liver was significantly thinner than before.

Surprising discovery: the microbiome started producing folic acid

The study, which was published in Cell Metabolism, included only ten people and is small, but it’s a very interesting piece to dig into as a biochemist like yours truly. It’s an extremely detailed map showing what happens when a person cuts down on sugar and starch in their diet. The liver metabolism changed almost immediately. Instead of creating fat, it started burning it and already in the first day you could see a significant reduction in liver fat. As a great side effect, the participants also improved their cholesterol profiles.

The microbiome also changed. A surprising discovery was that it started producing more folic acid, a vitamin which is important in the liver’s metabolism. Low levels of folic acid has earlier been associated with an increased risk of fatty liver.

Is sugar a worse than starch?

In my Swedish book, Det sötaste vi har (The Sweetest Thing We’ve Got), I write that some researchers suspect that our high consumption of sugar is an important reason explaining the epidemic of fatty liver. Sugar contains the sugar molecule fructose, which is metabolized in the liver. When we consume too much candy, soda and other sweets, our liver starts producing fat and after a while fat appears to get stuck in the liver.

In order to test this hypothesis, researchers at UCSF in San Francisco have earlier let children with fatty liver replace the sugar in food with starch (which contains the sugar molecule glucose). Just like the current study conducted in Gothenburg, the intention was to let the children continue to eat the same amount of calories and maintain their weight.

Despite the fact that the children ate carbs in the form of starch, the liver’s metabolism changed rapidly. Within nine days, almost half of the fat was gone. Some children also lost weight, but the amount of fat in the liver also decreased among the children who simply maintained their weight.

The Dietary Science Foundation invests in a study on fatty liver

So what conclusions can you draw from all this? First and foremost: it’s time to stop counting calories. Different types of calories have different effects on the body. Carbs do more harm than good for people with fatty liver, and there is reason to suspect that sugar is the worst of all carbs.

BUT. Both the Gothenburg and the USCF study are small and lacking a control group. In order to establish a new treatment, a better form of studies is required, randomized controlled trials. The Dietary Science Foundation just invested in this type of study at the Karolinska Institute in Stockholm, where a strict low-carb diet will be compared to 5:2 intermittent fasting and conventional treatment. If the study confirms the results above, it’s an important step in establishing a new dietary treatment in the medical care. And a chronic disease with over one billion sufferers, might turn out to be treatable in just a couple of weeks. Guess if that would reduce a lot of costs and strain on the medical system?

—
Ann Fernholm

Help change the world

Would you like to strengthen the role of dietary treatments within health care, by supporting the not-for-profit Dietary Science Foundation? Donate monthly or become a company partner. You can also follow the foundation on Facebook or Twitter.

Earlier

New study: Can low carb help reverse a fatty liver?

US experts raise red flag over fatty liver disease

All earlier posts about liver disease

Ann Fernholm

Ann Fernholm is a science journalist, author and PhD in molecular biotechnology. She is also the founder of The Dietary Science Foundation and runs a blog in Swedish.

Sugar

MEMBERS ONLY
MEMBERS ONLY
MEMBERS ONLY
MEMBERS ONLY
MEMBERS ONLY
MEMBERS ONLY
MEMBERS ONLY
Diet Doctor podcast #14 with Dr. Robert Lustig
47:31
The debate wages. Is a calorie just a calorie? Or is there something specifically dangerous about fructose and carbohydrate calories? That's where Dr. Robert Lustig comes in.
MEMBERS ONLY
MEMBERS ONLY

Name

Provider / Domain

Expiration

Description

ckdc-premium

.dietdoctor.com

1 month

app-banner

.dietdoctor.dev.dietdoctor.com

1 day

This cookie shows whether user closed the App Banner prompt

_gaexp

Google LLC

dietdoctor.com

1 year

Used to determine a user's inclusion in an experiment and the expiry of experiments a user has been included in.

_gaexp

Google LLC

.dietdoctor.com

1 year

Used to determine a user's inclusion in an experiment and the expiry of experiments a user has been included in.

_opt_awcid

.dietdoctor.com

3 days

_opt_awmid

.dietdoctor.com

3 days

_opt_awgid

.dietdoctor.com

3 days

_opt_awkid

.dietdoctor.com

3 days

_opt_utmc

.dietdoctor.com

3 days

_opt_expid

.dietdoctor.com

25 seconds

gtm_auth

.dietdoctor.com

3 days

gtm_debug

.dietdoctor.com

3 days

gtm_experiment

.dietdoctor.com

3 days

gtm_preview

.dietdoctor.com

3 days

_hjAbsoluteSessionInProgress

Hotjar Ltd

.dietdoctor.com

30 minutes

The cookie is set so Hotjar can track the beginning of the user's journey for a total session count. It does not contain any identifiable information.

_ga

Google LLC

.dietdoctor.com

2 years

This cookie name is associated with Google Universal Analytics - which is a significant update to Google's more commonly used analytics service. This cookie is used to distinguish unique users by assigning a randomly generated number as a client identifier. It is included in each page request in a site and used to calculate visitor, session and campaign data for the sites analytics reports.

_dc_gtm_UA-3268327-1

.dietdoctor.com

1 minute

This cookie is associated with sites using Google Tag Manager to load other scripts and code into a page. Where it is used it may be regarded as Strictly Necessary as without it, other scripts may not function correctly. The end of the name is a unique number which is also an identifier for an associated Google Analytics account.

_hjFirstSeen

Hotjar Ltd

.dietdoctor.com

30 minutes

The cookie is set so Hotjar can track the beginning of the user's journey for a total session count. It does not contain any identifiable information.

_dc_gtm_UA-22012422-2

.dietdoctor.com

1 minute

AWSELBCORS

Amazon.com Inc.

www.podbean.com

5 minutes

The cookies AWSELB and AWSELBCORS are functionally the same cookies. The latter has an explicit SameSite attribute set because of changes made from Chrome 80 and upwards.

_ga_YMCP8KW9S4

.dietdoctor.com

2 years

_hjIncludedInSessionSample

Hotjar Ltd

www.dietdoctor.com

2 minutes

This cookie is set to let Hotjar know whether that visitor is included in the data sampling defined by your site's daily session limit

__cf_bm

Cloudflare Inc.

.vimeo.com

30 minutes

This cookie is used to distinguish between humans and bots. This is beneficial for the website, in order to make valid reports on the use of their website.

_gid

Google LLC

.dietdoctor.com

1 day

This cookie is set by Google Analytics. It stores and update a unique value for each page visited and is used to count and track pageviews.

CookieScriptConsent

CookieScript

www.dietdoctor.com

1 year

This cookie is used by Cookie-Script.com service to remember visitor cookie consent preferences. It is necessary for Cookie-Script.com cookie banner to work properly.

__cf_bm

Cloudflare Inc.

.podbean.com

30 minutes

This cookie is used to distinguish between humans and bots. This is beneficial for the website, in order to make valid reports on the use of their website.

_hjIncludedInPageviewSample

Hotjar Ltd

www.dietdoctor.com

2 minutes

This cookie is set to let Hotjar know whether that visitor is included in the data sampling defined by your site's pageview limit.

_dc_gtm_UA-22012422-1

.dietdoctor.com

1 minute

_gaexp_rc

.dietdoctor.com

25 seconds

Name

Provider / Domain

Expiration

Description

IDE

Google LLC

.doubleclick.net

1 year

This cookie is set by Doubleclick and carries out information about how the end user uses the website and any advertising that the end user may have seen before visiting the said website.

_uetvid

Microsoft Corporation

.dietdoctor.com

1 year

This is a cookie utilised by Microsoft Bing Ads and is a tracking cookie. It allows us to engage with a user that has previously visited our website.

loc

Oracle Corporation

.addthis.com

1 year 1 month

Stores the visitors geolocation to record location of sharer

test_cookie

Google LLC

.doubleclick.net

15 minutes

This cookie is set by DoubleClick (which is owned by Google) to determine if the website visitor's browser supports cookies.

_gcl_au

Google LLC

.dietdoctor.com

3 months

Used by Google AdSense for experimenting with advertisement efficiency across websites using their services

_uetsid

Microsoft Corporation

.dietdoctor.com

1 day

This cookie is used by Bing to determine what ads should be shown that may be relevant to the end user perusing the site.

uvc

Oracle Corporation

.addthis.com

1 year 1 month

Tracks how often a user interacts with AddThis

YSC

Google LLC

.youtube.com

Session

This cookie is set by YouTube to track views of embedded videos.

MUID

Microsoft Corporation

.bing.com

1 year

This cookie is widely used my Microsoft as a unique user identifier. It can be set by embedded microsoft scripts. Widely believed to sync across many different Microsoft domains, allowing user tracking.

_fbp

Meta Platform Inc.

.dietdoctor.com

3 months

Used by Facebook to deliver a series of advertisement products such as real time bidding from third party advertisers

VISITOR_INFO1_LIVE

Google LLC

.youtube.com

6 months

This cookie is set by Youtube to keep track of user preferences for Youtube videos embedded in sites;it can also determine whether the website visitor is using the new or old version of the Youtube interface.

Name

Provider / Domain

Expiration

Description

_ga_7S1SXKKDKN

.dietdoctor.com

2 years

Name

Provider / Domain

Expiration

Description

_hjSession_1945121

.dietdoctor.com

30 minutes

_hjSessionUser_1945121

.dietdoctor.com

1 year

_ga_Y4DLH4EPXM

.dietdoctor.com

2 years