Alzheimers

Top keto videos

Alzheimer’s

MEMBERS ONLY
Facing the global mental health crisis
MEMBERS ONLY
Is lower insulin the key to better brain health?
MEMBERS ONLY
Q&A with Dr. Georgia Ede
  1. Alzheimers Dementia 2011: National estimates of the prevalence of Alzheimer’s Disease in the United States [overview article; ungraded]

    Alzheimers.org: 2019 Alzheimer’s Disease facts and figures [overview article; ungraded]

  2. Progress in Neurobiology 2014: Is Alzheimer’s Disease related to metabolic syndrome? A Wnt signaling conundrum [overview article; ungraded]

    Journal of Medicine and Life 2019: Possibilities of dementia prevention – it is never too early to start [overview article; ungraded]

  3. Diabetes Research and Clinical Practice 2018: Effect of dietary carbohydrate restriction on glycemic control in adults with diabetes: A systematic review and meta-analysis [strong evidence]

    Obesity Reviews 2016: Impact of low‐carbohydrate diet on body composition: meta‐analysis of randomized controlled studies [strong evidence]

    BMJ Open Diabetes Research and Care 2017: Systematic review and meta-analysis of dietary carbohydrate restriction in patients with type 2 diabetes [strong evidence]

    Journal of Medicinal Food 2011: A pilot study of the Spanish ketogenic Mediterranean diet: an effective therapy for the metabolic syndrome [non-randomized, non-controlled study; weak evidence]

  4. Annals of Neurology 2010: Dementia incidence continues to increase with age in the oldest old: the 90+ study [longitudinal study; weak evidence]

  5. Alzheimer’s & Dementia: Translational Research & Clinical Interventions 2017: Alzheimer’s Disease drug development pipeline: 2017 [overview article; ungraded]

  6. Expert Opinion on Investigational Drugs 2017: Why do trials for Alzheimer’s Disease drugs keep failing? A discontinued drug perspective for 2010-2015 [overview article; ungraded]

  7. Archives of Gerontology and Geriatrics 2017: Concern about developing Alzheimer’s Disease or dementia and intention to be screened: an analysis of national survey data [descriptive study; ungraded]

    European Journal of Aging 2012: Dementia worry: a psychological examination of an unexplored phenomenon [overview article; ungraded]

  8. Although the brain always needs some glucose, researchers have shown that during extended fasting or strict ketogenic eating, ketones can be used to meet up to 70% of the brain’s energy requirement:

    Journal of Clinical Investigations 1967: Brain metabolism during fasting. [nonrandomized study, weak evidence]

    Critical Care 2011: Clinical review: Ketones and brain injury. [overview article; ungraded]

    Journal of Cerebral Blood flow and Metabolism 2017: Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: A dual tracer quantitative positron emission tomography study [nonrandomized study, weak evidence]

  9. Frontiers in Endocrinology 2018: Unraveling the regulation of hepatic gluconeogenesis [overview article; ungraded]

  10. Epilepsia 2018: Effect of modified Atkins diet in adults with drug-resistant focal epilepsy: a randomized controlled trial [moderate evidence]

    Acta Neurologica Scandinavica 2017: A randomized controlled trial of the ketogenic diet in refracatory childhood epilepsy [moderate evidence]

    Epilepsy Research 2016: Evaluation of a simplified modified Atkins diet for use by parents with low levels of literacy in children with refractory epilepsy: a randomized controlled trial [moderate evidence]

  11. Frontiers in Pharmacology 2012: The ketogenic diet as a treatment paradigm for diverse neurological disorders [overview article; ungraded]

  12. [anecdotal reports; very weak evidence]

  13. Frontiers in Psychiatry 2017: The current status of the ketogenic diet in psychiatry
    [overview article; ungraded]

  14. Neurochemistry International 2018: Neuroketotherapeutics: a modern review of a century-old therapy [overview article; ungraded]

  15. Proceedings of the National Academy of Science U.S.A 2020: Diet modulates brain network stability, a biomarker for brain aging, in young adults [nonrandomized study, weak evidence]

  16. Diet Doctor will not benefit from your purchases. We do not show ads, use any affiliate links, sell products or take money from industry. Instead we’re funded by the people, via our optional membership. Learn more

  17. [anecdotal report; very weak evidence]

  18. European neuropsychopharmacology 2014: Type 3 diabetes is sporadic Alzheimer׳s Disease: mini-review [overview article; ungraded]

  19. Frontiers in Neuroscience 2018: Alzheimer’s Disease and type 2 diabetes: a critical assessment of the shared pathological traits [overview article; ungraded]

  20. Diabetes 2004: Increased risk of type 2 diabetes in Alzheimer disease [observational study; very weak evidence]

  21. Alzheimer’s Dementia 2019: Evidence for brain glucose dysregulation in Alzheimer’s Disease [observational study; very weak evidence]

  22. Archives of Neurology 2011: Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes [observational study; weak evidence]

    Nutrition 2011: Brain fuel metabolism, aging, and Alzheimer’s Disease[overview article; ungraded]

  23. PCOS is a reproductive metabolic disorder in which insulin resistance is a factor — and for which a low-carb or keto diet may be beneficial.

    PLoS One 2010: Regional brain glucose hypometabolism in young women with polycystic ovary syndrome: possible link to mild insulin resistance [case-control study; very weak evidence]

  24. Archives of Neurology 1983: The fluorodeoxyglucose 18F scan in Alzheimer’s Disease and multi-infarct dementia [observational study; weak evidence]

    In fact, some scientists propose using glucose metabolism as a surrogate marker for Alzheimer’s Disease

    Alzheimer’s and Dementia 2020: Influence of cerebral glucose metabolic rate on cognitive function in Alzheimer’s subjects [nonrandomized study, weak evidence]

  25. Journal of Alzheimer’s Disease 2015: Lower brain 18F-fluorodeoxyglucose uptake but normal 11C-acetoacetate metabolism in mild Alzheimer’s Disease dementia [case-control study; very weak evidence]

    Experimental gerontology 2018: A cross-sectional comparison of brain glucose and ketone metabolism in cognitively healthy older adults, mild cognitive impairment and early Alzheimer’s Disease [case-control study; very weak evidence]

  26. Annals of the New York Academy of Sciences 2016: Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer’s Disease [overview article; ungraded]

  27. Alzheimer’s Research and Therapy 2021: Randomized crossover trial of a modified ketogenic diet in Alzheimer’s Disease[moderate evidence]

  28. Neurobiology of Aging 2012: Dietary ketosis enhances memory in mild cognitive impairment [randomized trial; moderate evidence]

  29. Journal of Alzheimer’s Disease 2018: Ketogenic medium chain triglycerides increase brain energy metabolism in Alzheimer’s Disease [randomized trial; moderate evidence]

  30. Psychopharmacology 2016: Effect of a ketogenic meal on cognitive function in elderly adults: potential for cognitive enhancement [non-controlled study; weak evidence]

  31. Neuroscience Letters 2019: Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer’s Disease [controlled and non-controlled studies; weak evidence]

  32. Regarding this trial, Dr. Ede said, “While more studies are needed, this suggests that the diet performed as well or better in people with mild Alzheimer’s Disease than any of the currently available Alzheimer’s medicines. If a new drug intervention had achieved that degree of improvement, people would be jumping up and down with excitement.”

    Alzheimer’s & Dementia 2017: Feasibility and efficacy data from a ketogenic diet intervention in Alzheimer’s Disease [non-controlled study; weak evidence]

  33. Advances in Nutrition 2020:
    To Keto or Not to Keto? A Systematic Review of Randomized Controlled Trials Assessing the Effects of Ketogenic Therapy on Alzheimer Disease
    [systematic review of randomized trials; strong evidence]

  34. The Journal of Nutrition, Health & Aging 2009: Metabolic response to a ketogenic breakfast in the healthy elderly [non-controlled study; weak evidence]