Low carb and mental health:
Getting started and managing medications
- Should you try a low-carbohydrate
diet for your mental health? - Planning
- Reflection
- Consultation
- Baseline tests
- Medication management
- Antidepressants
- Antipsychotic medications
- Lithium
- Anticonvulsant mood stabilizers
- Blood-pressure medications
- When can I stop my medication?
- How do I stop my medication safely?
Are you suffering from a mental health issue like anxiety, depression, or ADHD? Do you wonder if changing your diet might help? In our guide, The food-mood connection, we discuss the new field of nutritional psychiatry and the emerging body of evidence that suggests eating a low-carbohydrate, whole-foods diet can improve mood and mental health.
Has hearing about low-carb diets sparked an interest in making a life-style change? We hope so! But if you are taking medication for mental health issues, you’ll need to do some planning before giving up your usual diet and easing into a low-carbohydrate eating plan. In this guide, we’ll cover how to prepare for the changes a low-carbohydrate eating pattern might make to your medications.
Should you try a low-carbohydrate diet for your mental health?
Although there is little human scientific data about low-carbohydrate diets and psychiatric disorders, what we do have is promising.
Planning
Embarking on a new diet is potentially challenging for many of us, but if you are dealing with mental health issues, it can be even more difficult. Changing how you eat requires motivation, planning, sustained commitment, and major changes to familiar and comforting routines, which can be stressful. To increase your chances for success, choose a start date that doesn’t coincide with other major changes or ordeals in your life. If you’re too depressed to muster the will to begin, or too anxious to tolerate the stress of transitioning to a new diet, the short-term use of medication to help you bridge the gap may be worth considering.
Reflection
Take time to ask yourself these questions to assess your readiness for change, track your progress, and stay motivated. It may be helpful to discuss these questions with your health care providers as well.
- Why are you thinking about changing your diet?
- What do you hope to accomplish by changing your diet?
- How do you feel on your current diet? List emotions and behaviors you’ve been struggling with lately.
- How do you feel about medications? If you take psychiatric medications, make a list of their pros and cons.
- What do you anticipate may be the biggest challenges for you in changing your diet?
- Do you have people at home or in your social circle that you could rely on for support? If not, you may want to consider a support group, counselor, or coach.
Consultation
If you currently take medications of any kind, discuss the idea with your prescriber before making any changes to your diet.
Ideally, your prescribing clinician will be supportive of the idea and knowledgeable about low-carbohydrate diets — or at least open to learning. If not, please refer them to our continuing medical education course so they can become more educated about the therapeutic use of low-carb nutrition.
If they still are not open to your suggestions, you may want to consider either finding a new prescriber or asking your current prescriber if they would be willing to collaborate with a knowledgeable nutritionist, primary care clinician, or other health professional who has clinical experience with ketogenic diets and can help guide them in your care.
Once you start, make a plan with your clinicians for close monitoring. Ideally, you’ll want weekly appointments with your prescriber (or his/her staff), your therapist (if you see someone separately for counseling), and other collaborating health professionals, especially during the first six weeks of your new diet.
Baseline tests
Your blood pressure, heart rate, body weight, and waist circumference should be recorded before you change your diet and monitored along the way. Your clinician should also order blood tests before you change your diet. Helpful tests include:
- Fasting comprehensive metabolic panel (glucose, electrolytes, kidney function, liver function, and acid-base balance)
- Fasting lipid panel (includes HDL cholesterol and triglycerides)
- Fasting total insulin level
- Thyroid function panel
- Highly-sensitive C-reactive protein (hs-CRP)
- Serum uric acid
- Medication blood levels if applicable (Lithium and Depakote are particularly important — see below)
- Any other tests your clinician recommends
Tests for nutrient deficiencies are worth considering as well. The most common vitamin and mineral deficiencies linked to psychiatric issues are vitamin B12, iron, zinc, and magnesium.

A low-carb diet for beginners
GuideA low-carb diet is low in carbohydrates, primarily found in sugary foods, pasta and bread. Instead, you eat real foods including protein, natural fats and vegetables. Learn more about low carb and how to use it for your personal goals in this guide.
Medication management
Low-carbohydrate diets can cause rapid shifts in brain and body chemistry, some of which may impact medication levels, dosages, and side effects that require close medical supervision.
If you currently take medication for depression, anxiety, mood swings, sleep, attention, or psychosis and you are considering trying a low-carbohydrate or ketogenic diet for the first time, please read through the information that follows and consult with your mental healthcare provider. This section is not meant to be comprehensive, and each situation is unique, so always consult with your own health care provider for personalized advice.
Antidepressants
Commonly-prescribed antidepressants include selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs) and Wellbutrin (bupropion).
Examples of SSRIs include Zoloft (sertraline), Lexapro (escitalopram), and Prozac (fluoxetine). Examples of SNRIs include Effexor (venlafaxine) and Cymbalta (duloxetine).
These medicines don’t usually pose any special problems on low-carbohydrate diets, but some people do feel hungrier and gain weight on SSRIs and Effexor, which may make it harder to stick to a new diet of any kind. Increased appetite and weight gain are uncommon with Wellbutrin and Cymbalta.
Antipsychotic medications
Antipsychotic medications such as Risperdal (risperidone), Abilify (aripiprazole), and Seroquel (quetiapine), can increase insulin levels and cause insulin resistance, which can make it harder for your body to generate ketones.
It’s certainly possible to experience benefits from dietary changes even while continuing to take antipsychotic medications, but in some cases these medicines may eventually need to be tapered off completely in order to realize the full potential benefits of a ketogenic diet.
Lithium
During the first few days of a ketogenic diet, most people will lose a few pounds of excess water weight through urination because ketogenic diets change the way the body processes fluid and electrolytes (salts), including lithium, which is a salt.
Anticonvulsant mood stabilizers
Many anticonvulsant medications originally designed to control seizures are also prescribed by psychiatrists for mood swings, insomnia, or anxiety. The ones most likely to behave strangely when embarking on a ketogenic diet are Depakote (valproate), Zonegran (zonisamide), and Topamax (topiramate).
Depakote (valproate) is actually a fatty acid that can be burned by your cells for fuel. Since your body ramps up fat metabolism on a ketogenic diet, cells hungry for fat can remove Depakote molecules from your bloodstream and may cause Depakote blood levels to fall.
Zonegran (zonisamide) and Topamax (topiramate) both change the way the kidney processes electrolytes (salts) and can make blood pH a little more acidic (metabolic acidosis), increasing risk for kidney stones.
Blood-pressure medications
Clonidine, Prazosin, and Propranolol were originally designed to treat high blood pressure, but they are also sometimes prescribed for insomnia, anxiety, nightmares, or ADHD
However, if you are taking a blood-pressure medicine, your blood pressure could fall too low, putting you at potential risk for lightheadedness, dizziness, and fatigue, with the worst-case scenario being that you could even pass out.
When can I stop my medication?
If you are excited about trying a low-carbohydrate diet in hopes that you may be able to reduce or eliminate one or more of your medications, that’s wonderful — but please be patient. Most medications should be continued until you’ve been solidly in ketosis for at least six weeks, which is the average amount of time it takes for the body to start using ketones efficiently for fuel.
While nutrition is a major contributor to mental health, it’s certainly not the only factor, so some people will continue to need medication support, even with the healthiest of diets.
How do I stop my medication safely?
Once you’ve adapted nicely to your new diet, depending on how you’re feeling, you and your clinician may decide to work toward possible medication reductions. Never stop any medicine abruptly! Always collaborate with your clinician, taper down very slowly, and change only one medicine at a time! Many psychiatric medicines can cause uncomfortable or even potentially dangerous withdrawal effects if not tapered slowly and carefully.
Be aware that most psychiatric medications continue to affect brain chemistry for an average of six weeks after you stop taking them. For this reason, if you are taking more than one psychiatric medication, it may be wise to wait at least six weeks after you’ve completed one medication taper before considering whether to start tapering another medication. For example: if you finish taking an antidepressant such as Zoloft in early May, you won’t know for sure how you’re actually feeling without it until at least late June. If you start to taper a second medication during that six-week window, and your depression symptoms begin to return, you won’t know whether it’s because the Zoloft benefits are wearing off, or because you’ve begun tapering a second medicine.
Low-carb diets may offer relief to many who are experiencing mental health issues. However, every patient is different. Anyone taking psychiatric medications should plan ahead and consult with their doctor before embarking on what might be a life-changing dietary intervention.
If you have questions, please visit our FAQ on low-carb and mental health; perhaps your question is answered there!